Aim: The objective of this study was to make 
                              an inventory of cases of metritis in dairy cows 
                              during the post-partum period, to verify with a 
                              detailed clinical study on its real incidence in 
                              Batna region and to study the treatment of 
                              metritis, using different treatment protocols. 
                              
                              
                              Materials and Methods: A total of 432 dairy 
                              cows were examined during the post partum period 
                              and forty dairy cows having metritis were selected 
                              and assigned into four groups of 10 each to be 
                              treated with different drugs. Visits were 
                              programmed to track the status of uterine 
                              involution and different parameters of fecundity 
                              and fertility of cows. 
                              
                              Result: The 
                              injection of Cloprostenol (a synthetic analogue of 
                              PGF2α) has a significant effect particularly on 
                              shorter intervals from calving to the first 
                              mating, calving to positive fertilization and for 
                              the reduction of the number of services of 
                              inseminations. Similarly, the association "antibiotic+Flunixin 
                              /Meglumine has a positive effect on the parameters 
                              mentioned above. 
                              
                              Conclusion: These results 
                              show that the double injection of Cloprostenol in 
                              the treatment of metritis improves the performance 
                              of fertility of animals and the dose of 3ml of 
                              PGF2α had succeeded in giving a positive effect on 
                              the different fertility parameters studied, 
                              compared to the dose of 2 ml. 
                              
                              Key words: 
                              cow, fertility, metritis, PGF2α, postpartum.